Effect of orally administered moxaverine on ocular haemodynamics
نویسندگان
چکیده
Background Reduced ocular perfusion is related to several common eye diseases, like age-related macular degeneration, diabetic retinopathy or glaucoma. Moxaverine, a phosphodiesterase inhibitor, has a vasodilating effect on peripheral vessels and is therefore clinically used to increase blood flow. It was recently shown that a dose of 150 mg moxaverine administered intravenously increases retinal blood flow in healthy subjects and in patients with ocular diseases. The aim of this study was to investigate the effect of oral moxaverine on ocular blood flow.
منابع مشابه
N-3-pyridylmethyl-N'-p-nitrophenylurea ocular toxicity in man and rabbits.
Ingestion of the rat poison N-3-pyridylmethyl-N'-p-nitrophenylurea (PNU) produced ocular toxicity in three humans and in an animal model, the Dutch Belted rabbit. The electroretinogram b wave was especially susceptible to the effects of the rodenticide, and the target tissue appeared to be the retinal pigment epithelium. Injection of PNU itself did not produce ocular toxicity. The poison had to...
متن کاملThe effects of oral and topical corticosteroid in rabbit corneas
BACKGROUND To determine the most effective route of administration of corticosteroids in the treatment of ocular surface disease, by characterizing the difference between oral prednisolone and topical dexamethasone administration using an animal model. METHODS Pharmacokinetic analyses determined the corticosteroid concentrations in the normal ocular tissues of rabbits after oral or topical ad...
متن کاملEffect of orally administered reduced- and oxidized-glutathione against acetaminophen-induced liver injury in rats.
To investigate the effects of orally administered reduced-glutathione (GSH) and oxidized-glutathione (GSSG) on liver GSH repletion and liver injury, acetaminophen (AAP) highly loaded rats were used. Orally administered GSH, dependent on dosage, indicated a protective effect against AAP-induced hepatotoxicity. This effect was associated with a recovery of liver GSH levels. Orally administered GS...
متن کاملThe Protective Effect of Orally Administered Amlodipine against Intestinal Ischemia-Reperfusion Injury in Rats
Objective- This study investigated the effect of amlodipine on intestinal ischemia-reperfusion injury in ratsDesign-Experimental studyAnimals-Fifteen male Sprague-Dawly rats weighing 200-220gProcedure- Rats were randomly divided into 3 groups: IR group (operation with clamping), sham group (operation without clamping), and IRA group (operation with clamping and 5mg/kg amlodipi...
متن کاملFear Response in Roosters Orally Exposed to Alcohol: An Alternative Animal Model
Effect of ethanol consumption on fear response in human and conventional animal models (rodents) is controversial. The present study aimed to investigate the effect of ethanol administration on fearfulness in poultry as an alternative animal model.Being a reliable measure in avian species, tonic immobility was used to evaluate the fear response in 60 roosters orally administered with ethanol. D...
متن کامل